Description

Epithalon | 50mg Research Grade · Swiss Manufactured · Lyophilized

Overview

Epithalon (also referred to as Epitalon or Epithalone) is a synthetic tetrapeptide analogue of Epithalamin — a naturally occurring polypeptide extract of the pineal gland — consisting of four amino acids in the sequence Ala-Glu-Asp-Gly. First identified and developed by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology, Epithalon has accumulated over four decades of research across Soviet, Russian, and international scientific institutions, establishing one of the most extensive longitudinal research foundations of any peptide in the biogerontology field. Its primary area of scientific interest lies in the regulation of telomerase activity, telomere biology, and the broader mechanisms of cellular senescence — positioning it as arguably the most studied peptide in longevity and anti-aging research. Beyond its telomeric activity, Epithalon has demonstrated a remarkably wide range of biological effects spanning neuroendocrine regulation, circadian rhythm modulation, antioxidant defense, and oncostatic activity, making it a uniquely multi-dimensional research tool in the peptide science landscape.

Sequence

Ala-Glu-Asp-Gly

Molecular Formula: C₁₄H₂₂N₄O₉ Molecular Weight: 390.35 g/mol CAS Number: 307297-39-8 Appearance: White lyophilized powder Purity: ≥ 99% (HPLC verified)

Mechanism of Action

Epithalon operates through several distinct but interrelated molecular mechanisms that collectively position it as a uniquely broad-spectrum research compound in cellular and systems biology:

Telomerase Activation & Telomere Elongation

Epithalon is the only peptide demonstrated in peer-reviewed research to activate telomerase (hTERT) in somatic cells — the enzyme responsible for maintaining and restoring telomere length
By upregulating telomerase expression, Epithalon has been shown in multiple cell culture studies to elongate telomeres in aging human cells, reversing a key molecular hallmark of cellular senescence
This activity has profound implications for replicative lifespan extension, DNA integrity maintenance, and senescent cell biology research

Pineal Gland & Neuroendocrine Regulation

As a structural analogue of Epithalamin, Epithalon directly influences pineal gland function, regulating the synthesis and secretion of melatonin via modulation of pinealocyte activity
This interaction supports research into circadian rhythm normalization, age-related melatonin decline, and the pineal-hypothalamic-pituitary axis
Downstream effects on cortisol regulation, gonadotropin secretion, and hypothalamic sensitivity have been characterized across multiple animal model studies

Antioxidant & Oxidative Stress Defense

Epithalon upregulates endogenous antioxidant enzyme activity — including superoxide dismutase (SOD) and glutathione peroxidase — reducing oxidative damage to lipids, proteins, and DNA
Reduction of lipid peroxidation markers and reactive oxygen species (ROS) accumulation has been consistently reported in aged tissue models, directly relevant to oxidative stress biology and longevity research

Chromatin & Gene Expression Regulation

Research suggests Epithalon modulates chromatin remodeling and heterochromatin structure, influencing the transcriptional accessibility of longevity-associated genes
This epigenetic dimension of its activity positions it at the intersection of geroscience and epigenomics, two of the most rapidly expanding fields in contemporary biological research

Oncostatic Activity

Multiple studies have investigated Epithalon’s capacity to inhibit aberrant cell proliferation and tumor development in carcinogen-exposed models, potentially via cell cycle checkpoint modulation and normalization of growth factor receptor expression

Research Applications

Epithalon’s unique combination of telomeric, neuroendocrine, and cytoprotective activity generates a research profile that spans several of the most active frontiers in modern biology:

Telomere Biology & Cellular Senescence

Telomerase activation mechanisms and hTERT expression regulation
Replicative senescence modeling and cellular lifespan extension studies
DNA damage response and genomic stability research
Senolytic and senomorphic pathway investigations

Longevity & Biogerontology Research

One of the most extensively studied peptides in lifespan extension models — preclinical studies have reported up to 33% mean lifespan extension in animal models
Hallmarks of aging research — telomere attrition, mitochondrial dysfunction, epigenetic alterations, and loss of proteostasis
Age-related functional decline modeling across multiple organ systems

Neuroendocrine & Pineal Biology

Pineal gland function, melatonin biosynthesis regulation, and photoperiodic signaling
Circadian rhythm disruption models and age-related chronobiological decline
HPA axis regulation and age-related neuroendocrine desynchronization

Oncology Research

Carcinogenesis prevention models, tumor suppression pathway studies
Aberrant cell proliferation and cell cycle dysregulation research
Interaction between telomere dynamics and oncogenic transformation

Retinal & Visual System Research

Studies have investigated its role in retinal pigment epithelium (RPE) cell preservation and photoreceptor function in aging retinal models
Relevant to age-related macular degeneration (AMD) and retinal senescence research

Immune System & Inflammation Research

Age-related immune decline (immunosenescence) and thymic function studies
Regulatory T-cell activity and cytokine balance in aging models
Chronic low-grade inflammation (inflammaging) pathway research

Oxidative Stress Biology

ROS accumulation, lipid peroxidation, and mitochondrial oxidative damage studies
Endogenous antioxidant enzyme regulation and redox homeostasis research

Research Heritage & Scientific Pedigree

Epithalon carries a scientific history that is unmatched among synthetic peptides in the longevity research space:

Developed from over 40 years of continuous research originating at the St. Petersburg Institute of Bioregulation and Gerontology under Professor V.Kh. Khavinson
Featured in peer-reviewed publications across journals including the Bulletin of Experimental Biology and Medicine, Neuro Endocrinology Letters, and Biogerontology
Preclinical studies have demonstrated lifespan extension, tumor incidence reduction, and functional preservation across multiple mammalian species
One of the few peptides with both in vitro telomerase activation data and longitudinal in vivo lifespan data, a combination that remains exceptionally rare in the peptide research literature

Comparative Profile — Longevity & Anti-Aging Peptide Class

Property	Epithalon	Thymalin	Selank	BPC-157
Telomerase Activation	⭐⭐⭐⭐⭐	❌	❌	❌
Pineal / Melatonin Regulation	⭐⭐⭐⭐⭐	⭐⭐	❌	❌
Antioxidant Activity	⭐⭐⭐⭐	⭐⭐⭐	⭐⭐⭐	⭐⭐⭐
Longevity Research Data	⭐⭐⭐⭐⭐	⭐⭐⭐⭐	⭐⭐	⭐⭐⭐
Neuroendocrine Modulation	⭐⭐⭐⭐	⭐⭐⭐	⭐⭐⭐⭐	⭐⭐
Immune System Research	⭐⭐⭐	⭐⭐⭐⭐⭐	⭐⭐⭐	⭐⭐⭐
Tissue Repair Activity	⭐⭐	⭐⭐	❌	⭐⭐⭐⭐⭐
Research Publication Volume	⭐⭐⭐⭐⭐	⭐⭐⭐⭐	⭐⭐⭐	⭐⭐⭐⭐⭐

Quality & Manufacturing

BioElevate Epithalon is synthesized in our Swiss GMP-compliant facility using solid-phase peptide synthesis (SPPS) with Fmoc chemistry. Despite its short tetrapeptide sequence, precise stereochemical fidelity and coupling efficiency at each step are rigorously controlled to ensure the biologically active L-amino acid configuration is maintained throughout. Every batch undergoes comprehensive independent quality verification:

Reverse-phase HPLC — purity ≥ 99% confirmed
High-resolution mass spectrometry (HRMS) — full molecular weight and sequence integrity confirmation
Chiral purity analysis — L-amino acid configuration verification
Endotoxin testing — LAL method, endotoxin-free certification
Sterility testing — USP <71> compliant
Amino acid analysis (AAA) — compositional verification
Certificate of Analysis (CoA) — issued per batch, available upon request

Supplied As

50mg lyophilized powder per vial
Sealed under inert nitrogen atmosphere to prevent oxidation
Recommended storage: −20°C, protected from light and moisture
Shelf life: 24 months (lyophilized); 30 days (reconstituted at 4°C)
Larger format vial ideal for extended research protocols and multi-experiment studies

Reconstitution

Reconstitute with sterile bacteriostatic water. For a 50mg vial, introduce solvent slowly along the inner vial wall in incremental additions, gently swirling between each addition until the lyophilized cake is fully dissolved. Do not vortex or shake vigorously. Allow the vial to equilibrate to room temperature prior to use. Once reconstituted, store at 4°C and use within 30 days. Aliquoting into smaller working volumes prior to storage is recommended to avoid repeated freeze-thaw cycles and preserve peptide integrity across extended research timelines.

⚠️ For Research Use Only. This product is intended solely for in vitro and laboratory research purposes. Not for human or veterinary use. Not for consumption. BioElevate products are sold exclusively to licensed research institutions and qualified professionals.