Description

Ipamorelin / CJC-1295 Blend | 10mg Research Grade · Swiss Manufactured · Lyophilized

Overview

The Ipamorelin/CJC-1295 blend represents one of the most extensively studied growth hormone secretagogue combinations in modern peptide research. This dual-action formulation pairs two mechanistically complementary peptides — Ipamorelin, a selective ghrelin receptor agonist (GHS-R1a), and CJC-1295, a long-acting GHRH analogue — to produce a sustained and amplified growth hormone release profile that neither compound achieves independently. Together, they target both arms of the GH secretion pathway simultaneously, making this blend a cornerstone research tool in the study of somatotropic axis regulation.

Blend Composition

Component	Class	Ratio
Ipamorelin	GHS / Ghrelin Receptor Agonist	50% (5mg)
CJC-1295 (without DAC)	GHRH Analogue	50% (5mg)

Individual Component Profiles

Ipamorelin Ipamorelin is a pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH₂) recognized for its high selectivity at the GHS-R1a receptor. Unlike earlier generation secretagogues, Ipamorelin does not significantly elevate cortisol, prolactin, or ACTH at research-relevant doses, making it a particularly clean tool for isolated GH pulse studies.

Molecular Formula: C₃₈H₄₉N₉O₅
Molecular Weight: 711.85 g/mol
CAS Number: 170851-70-4

CJC-1295 (without DAC) CJC-1295 without DAC (also known as Mod GRF 1-29) is a 29-amino acid GHRH analogue engineered with four amino acid substitutions to enhance enzymatic stability and receptor affinity. Without the Drug Affinity Complex (DAC), it maintains a physiologically relevant pulsatile GH release pattern, closely mimicking endogenous GHRH activity.

Molecular Formula: C₁₅₂H₂₅₂N₄₄O₄₂
Molecular Weight: 3367.97 g/mol
CAS Number: 863288-34-0

Mechanism of Action

The blend exploits a well-documented synergistic mechanism:

CJC-1295 binds GHRH receptors on pituitary somatotrophs, stimulating the synthesis and release of growth hormone
Ipamorelin simultaneously activates GHS-R1a receptors, amplifying GH pulse magnitude through a distinct intracellular pathway
The co-administration produces a synergistic GH release significantly greater than either peptide alone, while preserving the natural pulsatile secretion pattern critical to accurate somatotropic research

Research Applications

This blend is widely employed in preclinical and in vitro research to investigate:

Somatotropic axis regulation — GH/IGF-1 axis dynamics and pulsatile secretion modeling
Body composition studies — lean mass accretion, lipolysis, and metabolic substrate utilization
Skeletal & connective tissue research — bone mineral density, collagen synthesis, and joint tissue models
Sleep architecture studies — GH secretion patterns during slow-wave sleep phases
Age-related endocrine decline — somatopause research and GH restoration models
Recovery & repair biology — tissue regeneration and wound healing pathway studies

Quality & Manufacturing

Every vial of BioElevate Ipamorelin/CJC-1295 is produced in our Swiss GMP-compliant facility using solid-phase peptide synthesis (SPPS) with individual batch synthesis for each component prior to precision blending. Quality control includes:

HPLC analysis — purity ≥ 99% verified for each component independently
Mass spectrometry (MS) — molecular weight confirmation for both peptides
Endotoxin testing — LAL method, endotoxin-free certification
Sterility testing — USP <71> compliant
Certificate of Analysis (CoA) — available per batch, upon request

Supplied As

10mg lyophilized blend per vial (5mg Ipamorelin + 5mg CJC-1295)
Sealed under nitrogen atmosphere for oxidation protection
Recommended storage: −20°C, protected from light and moisture
Shelf life: 24 months (lyophilized); 30 days (reconstituted at 4°C)

Reconstitution

Reconstitute with sterile bacteriostatic water. Add solvent slowly along the vial wall and gently swirl until fully dissolved. Do not vortex or shake vigorously. Allow to equilibrate to room temperature before use.

⚠️ For Research Use Only. This product is intended solely for in vitro and laboratory research purposes. Not for human or veterinary use. Not for consumption. BioElevate products are sold exclusively to licensed research institutions and qualified professionals.