tesamorelin 10 MG

Description

Tesamorelin | 10mg Research Grade · Swiss Manufactured · Lyophilized

Overview

Tesamorelin is a synthetic analogue of endogenous growth hormone-releasing hormone (GHRH), composed of the full 44-amino acid sequence of human GHRH with a trans-3-hexenoic acid group conjugated to its N-terminus. This structural modification confers significantly enhanced plasma stability compared to native GHRH, dramatically extending its half-life while preserving full biological activity at the GHRH receptor. As one of the most pharmacologically well-characterized GHRH analogues available, Tesamorelin occupies a unique position in peptide research — bridging the gap between basic neuroendocrine science and translational metabolic biology. Its robust clinical research profile makes it one of the most data-backed peptides in the growth hormone secretagogue class.

Sequence

Trans-3-hexenoic acid-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH₂

Molecular Formula: C₂₂₁H₃₆₆N₇₂O₆₇S Molecular Weight: 5135.77 g/mol CAS Number: 218949-48-5 Appearance: White lyophilized powder Purity: ≥ 99% (HPLC verified)

Mechanism of Action

Tesamorelin exerts its effects through direct, high-affinity binding to pituitary GHRH receptors (GHRHR), initiating a well-defined downstream signaling cascade:

• GHRHR activation triggers intracellular cAMP elevation via Gs-protein coupling, stimulating somatotroph cells of the anterior pituitary
• This drives both synthesis and pulsatile release of endogenous growth hormone, preserving the physiological secretion pattern
• Elevated GH subsequently stimulates hepatic IGF-1 production, mediating downstream anabolic and metabolic effects
• The N-terminal trans-3-hexenoic acid modification provides resistance to dipeptidyl peptidase IV (DPP-IV) cleavage, the primary enzymatic degradation pathway of native GHRH — substantially extending functional half-life without altering receptor binding kinetics

Research Applications

Tesamorelin is a highly versatile research peptide with one of the broadest and most rigorously documented research profiles in its class. Key areas of investigation include:

• Visceral adiposity research — reduction of excess visceral adipose tissue (VAT), particularly in metabolic dysregulation models; among the most studied GHRH analogues in this context
• Somatotropic axis studies — GH/IGF-1 axis restoration, pulsatile secretion dynamics, and age-related GH decline models
• Metabolic & lipid biology — triglyceride metabolism, lipodystrophy models, and atherogenic dyslipidemia research
• Cognitive & neuroscience research — emerging investigations into GH/IGF-1 axis influence on executive function, memory consolidation, and neuroplasticity
• Cardiovascular biology — carotid intima-media thickness models, endothelial function, and cardiometabolic risk factor studies
• Body composition research — lean mass preservation, fat mass reduction, and substrate metabolism in aging and metabolic disease models
• Inflammatory pathway studies — IGF-1 mediated modulation of inflammatory cytokine expression

Distinguishing Features vs. Other GHRH Analogues

Quality & Manufacturing

BioElevate Tesamorelin is synthesized in our Swiss GMP-compliant facility using advanced solid-phase peptide synthesis (SPPS) with Fmoc chemistry, ensuring precise replication of the full 44-amino acid sequence with correct N-terminal modification. Each batch undergoes comprehensive independent quality verification:

• Reverse-phase HPLC — purity ≥ 99% confirmed
• High-resolution mass spectrometry (HRMS) — full molecular weight and sequence confirmation
• Endotoxin testing — LAL method, endotoxin-free certification
• Sterility testing — USP <71> compliant
• Amino acid analysis (AAA) — sequence integrity verification
• Certificate of Analysis (CoA) — issued per batch, available upon request

Supplied As

• 10mg lyophilized powder per vial
• Sealed under inert nitrogen atmosphere to prevent oxidation
• Recommended storage: −20°C, protected from light and moisture
• Shelf life: 24 months (lyophilized); 30 days (reconstituted at 4°C)

Reconstitution

Reconstitute with sterile bacteriostatic water. Introduce solvent slowly along the inner vial wall to minimize foaming. Gently swirl until the lyophilized cake is fully dissolved. Do not vortex. Allow vial to reach room temperature prior to use. For long-term reconstituted storage, maintain at 4°C and protect from repeated freeze-thaw cycles.

⚠️ For Research Use Only. This product is intended solely for in vitro and laboratory research purposes. Not for human or veterinary use. Not for consumption. BioElevate products are sold exclusively to licensed research institutions and qualified professionals.